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Ivermectin is so useful and adaptable that it is also being used off-label, sometimes, illegally, for example to treat fish lice in the aquaculture industry, where it can have a negative impact on non-target organisms Ivermectin also has extensive uses in agriculture Today, ivermectin is being increasingly used worldwide to combat other diseases in humans, such as Strongyloidiasis which infects some 35 million each year , scabies which causes million cases annually , Pediculosis, Gnathostomiasis and Myiasis—and new and promising properties and uses for ivermectin and other avermectin derivatives are continuing to be found These include activity against another neglected tropical disease, Leishmaniasis Of perhaps even greater significance is the evidence that the use of ivermectin has both direct and indirect beneficial impact on improving community health.
Studies of long-term treatment with ivermectin to control Onchocerciasis have shown that use of the drug is additionally associated with significant reduction in the prevalence of infection with any soil-transmitted helminth parasites including Ascaris, Trichuris and hookworm , most or all of which are deemed to be major causes of the morbidity arising from poor childhood nutrition and growth It is also known that the prevalence of head lice is markedly reduced in children taking ivermectin tablets 17 and that scabies is markedly reduced in populations taking the drug regularly In many underprivileged communities throughout the tropics, intestinal worms and parasitic skin diseases are extremely common and associated with significant morbidity.
They usually co-exist, with many individuals infected with both ecto- and endoparasites Mass treatment of poly-parasitized populations is deemed to be the best means of control and ivermectin is the ideal drug for such interventions.
A recent study in Brazil, using locally produced ivermectin, looked at the impact on internal helminthes and parasitic skin diseases. Ivermectin is typically given as one or two oral doses.
Ivermectin therapy has been associated with minor, self-limiting serum aminotransferase elevations and very rare instances of clinically apparent liver injury Ivermectin is used to treat strongyloidiasis threadworm; infection with a type of roundworm that enters the body through the skin, moves through the airways and lives in the intestines.
Ivermectin is also used to control onchocerciasis river blindness; infection with a type of roundworm that may cause rash, bumps under the skin, and vision problems including vision loss or blindness.
Ivermectin is in a class of medications called anthelmintics. It treats strongyloidosis by killing the worms in the intestines.
Ivermectin treats onchocerciasis by killing the developing worms. Ivermectin does not kill the adult worms that cause onchocerciasis and therefore it will not cure this type of infection.
Ivermectin is also sometimes used to treat certain other roundworm infections, head or pubic lice infestation, and scabies itchy skin condition caused by infestation with small mites that live under the skin.
Talk to your doctor about the risks of using this medication for your condition. Ivermectin comes as a tablet to take by mouth.
It is usually taken as a single dose on an empty stomach with water. If you are taking ivermectin to treat onchocerciasis, additional doses 3, 6, or 12 months later may be necessary to control your infection.
Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
Take ivermectin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Retreatment is required because ivermectin has no activity against adult onchocerca volvulus parasites which tend to reside in subcutaneous nodules.
Surgical excision of these nodules may be considered to eliminate the adult reproduction of microfilariae. Patients with crusted scabies may require two or more doses of ivermectin spaced at one to two week intervals.
If you are taking ivermectin to treat strongyloidiasis, you will need to have a stool exam at least three times during the first 3 months after your treatment to see if your infection has cleared.
If your infection has not cleared, your doctor will probably prescribe additional doses of ivermectin. Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of ivermectin topical lotion in children.
However, use is not recommended in infants younger than 6 months of age. Appropriate studies have not been performed on the relationship of age to the effects of ivermectin topical cream in the pediatric population.
Safety and efficacy have not been established. Pregnancy Category C: Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.
Breastfeeding: There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Ivermectin is excreted into human milk in low concentrations.
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